This policy outlines Malawi’s national framework for Infection Prevention and Control (IPC) in healthcare settings. Developed by the Ministry of Health’s Quality Management Directorate, the document aims to reduce healthcare-associated infections (HAIs) and antimicrobial resistance (AMR), promote evidence-based practices, and integrate IPC into the national health system. It includes clear governance structures, implementation plans, monitoring frameworks, and links to the Health Sector Strategic Plan III and Vision 2063.