This new brief from WHO provides insights into available strategies and approaches to hand hygiene improvement in health care facilities (HCFs) in support of the new United Nations Children’s Fund (UNICEF)/World Health Organization (WHO) Hand Hygiene for All Initiative, including sustainable interventions. The brief draws on learning from legacy work and the current evidence base. It emphasizes the synergistic relationship between IPC and WASH in HCFs and summarizes how joint action and collaboration is essential for improvement in the context of the coronavirus disease (COVID-19) response and beyond.