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This document was developed in line with the Zambia National Health Strategic Plan (ZNHSP) 2022. It highlights and provides strategic guidelines in the implementation of Infection Prevention and Control (IPC) activities for the next ten years at the national and sub-national levels. The main focus of IPC is to prevent and control the spread of diseases among patients, health care providers, and caregivers in both public and health care facilities, including communities, using a holistic approach that integrates all IPC thematic areas in mitigating and preventing healthcare-associated infections and antimicrobial resistance.